Tarzan receives a letter from Jane. She is nursing British troops in London and needs Tarzan to get some of the medicine they were using, when Boy had fever. It’s a rare malaria serum.
The medicine was extracted from a special plant, which grows only across the great desert. Thus the Ape Man, Boy and Cheetah start their journey across the desert, looking for the serum, but finding man-eating plants, prehistoric monsters and Nazis instead.
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